Genome‐Wide CRISPR‐Cas9 Screening Identifies NF‐κB/E2F6 Responsible for EGFRvIII‐Associated Temozolomide Resistance in Glioblastoma

Amplification of epidermal growth factor receptor (EGFR) and active mutant EGFRvIII occurs frequently in glioblastoma (GBM) and contributes to chemo/radio‐resistance in various cancers, especially in GBM. Elucidating the underlying molecular mechanism of temozolomide (TMZ) resistance in GBM could be...

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Detalles Bibliográficos
Autores principales: Huang, Kai, Liu, Xing, Li, Yansheng, Wang, Qixue, Zhou, Junhu, Wang, Yunfei, Dong, Feng, Yang, Chao, Sun, Zhiyan, Fang, Chuan, Liu, Chaoyong, Tan, Yanli, Wu, Xudong, Jiang, Tao, Kang, Chunsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724471/
https://www.ncbi.nlm.nih.gov/pubmed/31508283
http://dx.doi.org/10.1002/advs.201900782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724471/
https://www.ncbi.nlm.nih.gov/pubmed/31508283
http://dx.doi.org/10.1002/advs.201900782

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