Stretching magnitude–dependent inactivation of AKT by ROS led to enhanced p53 mitochondrial translocation and myoblast apoptosis

Previously, we had shown that high magnitude stretch (HMS), rather than low magnitude stretch (LMS), induced significant apoptosis of skeletal muscle C2C12 myoblasts. However, the molecular mechanism remains obscure. In this study, we found that p53 protein accumulated in the nucleus of LMS-loaded c...

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Detalles Bibliográficos
Autores principales: Song, Jing, Wang, Yaqi, Yuan, Xiao, Ji, Qiuxia, Fan, Cunhui, Zhao, Hongmei, Hao, Wenjing, Ren, Dapeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724521/
https://www.ncbi.nlm.nih.gov/pubmed/30865562
http://dx.doi.org/10.1091/mbc.E18-12-0770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724521/
https://www.ncbi.nlm.nih.gov/pubmed/30865562
http://dx.doi.org/10.1091/mbc.E18-12-0770

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