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Mitochondrial carrier protein overloading and misfolding induce aggresomes and proteostatic adaptations in the cytosol

Previous studies in yeast showed that mitochondrial stressors not directly targeting the protein import machinery can cause mitochondrial precursor overaccumulation stress (mPOS) in the cytosol independent of bioenergetics. Here, we demonstrate mPOS and stress responses in human cells. We show that...

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Detalles Bibliográficos
Autores principales: Liu, Yaxin, Wang, Xiaowen, Coyne, Liam P., Yang, Yuan, Qi, Yue, Middleton, Frank A., Chen, Xin Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724602/
https://www.ncbi.nlm.nih.gov/pubmed/30893019
http://dx.doi.org/10.1091/mbc.E19-01-0046