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Mitochondrial carrier protein overloading and misfolding induce aggresomes and proteostatic adaptations in the cytosol
Previous studies in yeast showed that mitochondrial stressors not directly targeting the protein import machinery can cause mitochondrial precursor overaccumulation stress (mPOS) in the cytosol independent of bioenergetics. Here, we demonstrate mPOS and stress responses in human cells. We show that...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724602/ https://www.ncbi.nlm.nih.gov/pubmed/30893019 http://dx.doi.org/10.1091/mbc.E19-01-0046 |