Targeted delivery of CRISPR interference system against Fabp4 to white adipocytes ameliorates obesity, inflammation, hepatic steatosis, and insulin resistance

Obesity is an increasing pathophysiological problem in developed societies. Despite all major progress in understanding molecular mechanisms of obesity, currently available anti-obesity drugs have shown limited efficacy with severe side effects. CRISPR interference (CRISPRi) mechanism based on catal...

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Detalles Bibliográficos
Autores principales: Chung, Jee Young, Ain, Qurrat Ul, Song, Yoonsung, Yong, Seok-Beom, Kim, Yong-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724665/
https://www.ncbi.nlm.nih.gov/pubmed/31467027
http://dx.doi.org/10.1101/gr.246900.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724665/
https://www.ncbi.nlm.nih.gov/pubmed/31467027
http://dx.doi.org/10.1101/gr.246900.118

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