Direct RNA nanopore sequencing of full-length coronavirus genomes provides novel insights into structural variants and enables modification analysis

Sequence analyses of RNA virus genomes remain challenging owing to the exceptional genetic plasticity of these viruses. Because of high mutation and recombination rates, genome replication by viral RNA-dependent RNA polymerases leads to populations of closely related viruses, so-called “quasispecies...

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Detalles Bibliográficos
Autores principales: Viehweger, Adrian, Krautwurst, Sebastian, Lamkiewicz, Kevin, Madhugiri, Ramakanth, Ziebuhr, John, Hölzer, Martin, Marz, Manja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724671/
https://www.ncbi.nlm.nih.gov/pubmed/31439691
http://dx.doi.org/10.1101/gr.247064.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724671/
https://www.ncbi.nlm.nih.gov/pubmed/31439691
http://dx.doi.org/10.1101/gr.247064.118

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