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Microtubule polymerase and processive plus-end tracking functions originate from distinct features within TOG domain arrays

XMAP215/Stu2/Alp14 accelerates tubulin polymerization while processively tracking microtubule (MT) plus ends via tumor overexpressed gene (TOG) domain arrays. It remains poorly understood how these functions arise from tubulin recruitment, mediated by the distinct TOG1 and TOG2 domains, or the assem...

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Detalles Bibliográficos
Autores principales: Cook, Brian D., Chang, Fred, Flor-Parra, Ignacio, Al-Bassam, Jawdat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724690/
https://www.ncbi.nlm.nih.gov/pubmed/30969896
http://dx.doi.org/10.1091/mbc.E19-02-0093