Cargando…
Microtubule polymerase and processive plus-end tracking functions originate from distinct features within TOG domain arrays
XMAP215/Stu2/Alp14 accelerates tubulin polymerization while processively tracking microtubule (MT) plus ends via tumor overexpressed gene (TOG) domain arrays. It remains poorly understood how these functions arise from tubulin recruitment, mediated by the distinct TOG1 and TOG2 domains, or the assem...
Autores principales: | Cook, Brian D., Chang, Fred, Flor-Parra, Ignacio, Al-Bassam, Jawdat |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724690/ https://www.ncbi.nlm.nih.gov/pubmed/30969896 http://dx.doi.org/10.1091/mbc.E19-02-0093 |
Ejemplares similares
-
Fission yeast Alp14 is a dose-dependent plus end–tracking microtubule polymerase
por: Al-Bassam, Jawdat, et al.
Publicado: (2012) -
Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays
por: Nithianantham, Stanley, et al.
Publicado: (2018) -
Crescerin uses a TOG domain array to regulate microtubules in the primary cilium
por: Das, Alakananda, et al.
Publicado: (2015) -
Structures of TOG1 and TOG2 from the human microtubule dynamics regulator CLASP1
por: Leano, Jonathan B., et al.
Publicado: (2019) -
Two XMAP215/TOG Microtubule Polymerases, Alp14 and Dis1, Play Non-Exchangeable, Distinct Roles in Microtubule Organisation in Fission Yeast
por: Yukawa, Masashi, et al.
Publicado: (2019)