Cargando…

Vinculin and metavinculin exhibit distinct effects on focal adhesion properties, cell migration, and mechanotransduction

Vinculin (Vcn) is a ubiquitously expressed cytoskeletal protein that links transmembrane receptors to actin filaments, and plays a key role in regulating cell adhesion, motility, and force transmission. Metavinculin (MVcn) is a Vcn splice isoform that contains an additional exon encoding a 68-residu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Hyunna T., Sharek, Lisa, O’Brien, E. Timothy, Urbina, Fabio L., Gupton, Stephanie L., Superfine, Richard, Burridge, Keith, Campbell, Sharon L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726196/ https://www.ncbi.nlm.nih.gov/pubmed/31483833 http://dx.doi.org/10.1371/journal.pone.0221962

Ejemplares similares

Vinculin phosphorylation differentially regulates mechanotransduction at cell–cell and cell–matrix adhesions
por: Bays, Jennifer L., et al.
Publicado: (2014)

The C-terminal tail domain of metavinculin, vinculin’s splice variant, severs actin filaments
por: Janssen, Mandy E.W., et al.
Publicado: (2012)

Phosphorylation at Y1065 in Vinculin Mediates Actin Bundling, Cell Spreading, and Mechanical Responses to Force
por: Tolbert, Caitlin E., et al.
Publicado: (2014)

Correction to Phosphorylation at Y1065 in Vinculin Mediates Actin Bundling, Cell Spreading, and Mechanical Responses to Force
por: Tolbert, Caitlin E., et al.
Publicado: (2014)

Metavinculin modulates force transduction in cell adhesion sites
por: Kanoldt, Verena, et al.
Publicado: (2020)

Vinculin–actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth
por: Thievessen, Ingo, et al.
Publicado: (2013)

Molecular mechanism of vinculin activation and nano-scale spatial organization in focal adhesions
por: Case, Lindsay B., et al.
Publicado: (2015)

PAK2 links cell survival to mechanotransduction and metabolism
por: Campbell, Hannah K., et al.
Publicado: (2019)

Lipid binding promotes oligomerization and focal adhesion activity of vinculin
por: Chinthalapudi, Krishna, et al.
Publicado: (2014)

Conformational states during vinculin unlocking differentially regulate focal adhesion properties
por: Chorev, Dror S., et al.
Publicado: (2018)

A Helix Replacement Mechanism Directs Metavinculin Functions
por: Rangarajan, Erumbi S., et al.
Publicado: (2010)

Vinculin controls focal adhesion formation by direct interactions with talin and actin
por: Humphries, Jonathan D., et al.
Publicado: (2007)

Paxillin: a new vinculin-binding protein present in focal adhesions
Publicado: (1990)

Focal adhesion proteins Zyxin and Vinculin are co-distributed at tubulobulbar complexes
por: Young, J’Nelle S., et al.
Publicado: (2012)

CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics
por: Janoštiak, Radoslav, et al.
Publicado: (2013)

Cardiac Differentiation Promotes Focal Adhesions Assembly through Vinculin Recruitment
por: Carton, Flavia, et al.
Publicado: (2023)

Mechanotransduction at focal adhesions: from physiology to cancer development
por: Seong, Jihye, et al.
Publicado: (2013)

The role of focal adhesion anchoring domains of CAS in mechanotransduction
por: Braniš, Jaroslav, et al.
Publicado: (2017)

Regulation of RhoA Activity by Adhesion Molecules and Mechanotransduction
por: Marjoram, R.J., et al.
Publicado: (2014)

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics
por: Grashoff, Carsten, et al.
Publicado: (2010)

Compliant substratum modulates vinculin expression in focal adhesion plaques in skeletal cells
por: Zhou, Chenchen, et al.
Publicado: (2019)

α–Catenin-dependent vinculin recruitment to adherens junctions is antagonistic to focal adhesions
por: Bejar-Padilla, Vidal, et al.
Publicado: (2022)

Mechanotransduction at focal adhesions: integrating cytoskeletal mechanics in migrating cells
por: Kuo, Jean-Cheng
Publicado: (2013)

Dystrophin missense mutations alter focal adhesion tension and mechanotransduction
por: Ramirez, Maria Paz, et al.
Publicado: (2022)

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin
por: Margadant, Felix, et al.
Publicado: (2011)

Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion
por: DeMali, Kris A., et al.
Publicado: (2002)

Dynamics and distribution of paxillin, vinculin, zyxin and VASP depend on focal adhesion location and orientation
por: Legerstee, Karin, et al.
Publicado: (2019)

Focal Adhesion Protein Vinculin Is Required for Proper Meiotic Progression during Mouse Spermatogenesis
por: Petrusová, Jana, et al.
Publicado: (2022)

Vinculin in cell–cell and cell–matrix adhesions
por: Bays, Jennifer L., et al.
Publicado: (2017)

A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes
por: Kim, Jichul
Publicado: (2021)

Identification of two distinct functional domains on vinculin involved in its association with focal contacts
Publicado: (1989)

Vinculin Regulates the Recruitment and Release of Core Focal Adhesion Proteins in a Force-Dependent Manner
por: Carisey, Alex, et al.
Publicado: (2013)

Zyxin‐involved actin regulation is essential in the maintenance of vinculin focal adhesion and chondrocyte differentiation status
por: Li, Gaoming, et al.
Publicado: (2018)

Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction
por: Graham, David M., et al.
Publicado: (2018)

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation
por: Pasapera, Ana M., et al.
Publicado: (2010)

The Cryogenic Electron Microscopy Structure of the Cell Adhesion Regulator Metavinculin Reveals an Isoform-Specific Kinked Helix in Its Cytoskeleton Binding Domain
por: Rangarajan, Erumbi S., et al.
Publicado: (2021)

Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding
Publicado: (1996)

Talin: a protein designed for mechanotransduction
por: Burridge, Keith
Publicado: (2018)

Mechanosensitive components of integrin adhesions: Role of vinculin
por: Atherton, Paul, et al.
Publicado: (2016)

Nuclear mechanotransduction: Forcing the nucleus to respond
por: Guilluy, Christophe, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_sp25fscperritiribtg6253pjm