CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity

CCN1 (CYR61) stimulates active angiogenesis in various tumours, although the mechanism is largely unknown. Here, we report that CCN1 is a key regulator of endothelial tip cell activity in angiogenesis. Microvessel networks and directional vascular cell migration patterns were deformed in ccn1-knockd...

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Detalles Bibliográficos
Autores principales: Park, Myo-Hyeon, Kim, Ae kyung, Manandhar, Sarala, Oh, Su-Young, Jang, Gun-Hyuk, Kang, Li, Lee, Dong-Won, Hyeon, Do Young, Lee, Sun-Hee, Lee, Hye Eun, Huh, Tae-Lin, Suh, Sang Heon, Hwang, Daehee, Byun, Kyunghee, Park, Hae-Chul, Lee, You Mie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726423/
https://www.ncbi.nlm.nih.gov/pubmed/31429823
http://dx.doi.org/10.7554/eLife.46012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726423/
https://www.ncbi.nlm.nih.gov/pubmed/31429823
http://dx.doi.org/10.7554/eLife.46012

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