Antibodies to the conserved region of the M protein and a streptococcal superantigen cooperatively resolve toxic shock-like syndrome in HLA-humanized mice

Invasive streptococcal disease (ISD) and toxic shock syndrome (STSS) result in over 160,000 deaths each year. We modelled these in HLA-transgenic mice infected with a clinically lethal isolate expressing Streptococcal pyrogenic exotoxin (Spe) C and demonstrate that both SpeC and streptococcal M prot...

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Detalles Bibliográficos
Autores principales: Pandey, Manisha, Calcutt, Ainslie, Ozberk, Victoria, Chen, Zhenjun, Croxen, Matthew, Powell, Jessica, Langshaw, Emma, Mills, Jamie-Lee, Jen, Freda E.-C., McCluskey, James, Robson, Jenny, Tyrrell, Gregory J., Good, Michael F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726444/
https://www.ncbi.nlm.nih.gov/pubmed/31517054
http://dx.doi.org/10.1126/sciadv.aax3013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726444/
https://www.ncbi.nlm.nih.gov/pubmed/31517054
http://dx.doi.org/10.1126/sciadv.aax3013

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