The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia

Iron acquisition is critical for life. Ferroportin (FPN) exports iron from mature erythrocytes, and deletion of the Fpn gene results in hemolytic anemia and increased fatality in malaria-infected mice. The FPN Q248H mutation (glutamine to histidine at position 248) renders FPN partially resistant to...

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Detalles Bibliográficos
Autores principales: Muriuki, John Muthii, Mentzer, Alexander J., Band, Gavin, Gilchrist, James J., Carstensen, Tommy, Lule, Swaib A., Goheen, Morgan M., Joof, Fatou, Kimita, Wandia, Mogire, Reagan, Cutland, Clare L., Diarra, Amidou, Rautanen, Anna, Pomilla, Cristina, Gurdasani, Deepti, Rockett, Kirk, Mturi, Neema, Ndungu, Francis M., Scott, J. Anthony G., Sirima, Sodiomon B., Morovat, Alireza, Prentice, Andrew M., Madhi, Shabir A., Webb, Emily L., Elliott, Alison M., Bejon, Philip, Sandhu, Manjinder S., Hill, Adrian V. S., Kwiatkowski, Dominic P., Williams, Thomas N., Cerami, Carla, Atkinson, Sarah H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726445/
https://www.ncbi.nlm.nih.gov/pubmed/31517041
http://dx.doi.org/10.1126/sciadv.aaw0109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726445/
https://www.ncbi.nlm.nih.gov/pubmed/31517041
http://dx.doi.org/10.1126/sciadv.aaw0109

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