Overexpression of O‐polysaccharide chain length regulators in Gram‐negative bacteria using the Wzx‐/Wzy‐dependent pathway enhances production of defined modal length O‐polysaccharide polymers for use as haptens in glycoconjugate vaccines

AIMS: O‐polysaccharide (OPS) molecules are protective antigens for several bacterial pathogens, and have broad utility as components of glycoconjugate vaccines. Variability in the OPS chain length is one obstacle towards further development of these vaccines. Introduction of sizing steps during puri...

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Detalles Bibliográficos
Autores principales: Hegerle, N., Bose, J., Ramachandran, G., Galen, J.E., Levine, M.M., Simon, R., Tennant, S.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726474/
https://www.ncbi.nlm.nih.gov/pubmed/29603538
http://dx.doi.org/10.1111/jam.13772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726474/
https://www.ncbi.nlm.nih.gov/pubmed/29603538
http://dx.doi.org/10.1111/jam.13772

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