Activation of PKA via asymmetric allosteric coupling of structurally conserved cyclic nucleotide binding domains

Cyclic nucleotide-binding (CNB) domains allosterically regulate the activity of proteins with diverse functions, but the mechanisms that enable the cyclic nucleotide-binding signal to regulate distant domains are not well understood. Here we use optical tweezers and molecular dynamics to dissect cha...

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Detalles Bibliográficos
Autores principales: Hao, Yuxin, England, Jeneffer P., Bellucci, Luca, Paci, Emanuele, Hodges, H. Courtney, Taylor, Susan S., Maillard, Rodrigo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726620/
https://www.ncbi.nlm.nih.gov/pubmed/31484930
http://dx.doi.org/10.1038/s41467-019-11930-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726620/
https://www.ncbi.nlm.nih.gov/pubmed/31484930
http://dx.doi.org/10.1038/s41467-019-11930-2

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