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Activation of PKA via asymmetric allosteric coupling of structurally conserved cyclic nucleotide binding domains
Cyclic nucleotide-binding (CNB) domains allosterically regulate the activity of proteins with diverse functions, but the mechanisms that enable the cyclic nucleotide-binding signal to regulate distant domains are not well understood. Here we use optical tweezers and molecular dynamics to dissect cha...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726620/ https://www.ncbi.nlm.nih.gov/pubmed/31484930 http://dx.doi.org/10.1038/s41467-019-11930-2 |