Different Grp94 components interact transiently with the myocilin olfactomedin domain in vitro to enhance or retard its amyloid aggregation

The inherited form of open angle glaucoma arises due to a toxic gain-of-function intracellular misfolding event involving a mutated myocilin olfactomedin domain (OLF). Mutant myocilin is recognized by the endoplasmic reticulum (ER)-resident heat shock protein 90 paralog, glucose regulated protein 94...

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Detalles Bibliográficos
Autores principales: Huard, Dustin J. E., Jonke, Alex P., Torres, Matthew P., Lieberman, Raquel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726633/
https://www.ncbi.nlm.nih.gov/pubmed/31484937
http://dx.doi.org/10.1038/s41598-019-48751-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726633/
https://www.ncbi.nlm.nih.gov/pubmed/31484937
http://dx.doi.org/10.1038/s41598-019-48751-8

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