Cargando…

CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis

The diverse expression pattern of CD36 reflects its multiple cellular functions. However, the roles of CD36 in colorectal cancer (CRC) remain unknown. Here, we discover that CD36 expression is progressively decreased from adenomas to carcinomas. CD36 loss predicts poor survival of CRC patients. In C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fang, Yuan, Shen, Zhi-Yong, Zhan, Yi-Zhi, Feng, Xiao-Chuang, Chen, Ke-Li, Li, Yong-Sheng, Deng, Hai-Jun, Pan, Su-Ming, Wu, De-Hua, Ding, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726635/ https://www.ncbi.nlm.nih.gov/pubmed/31484922 http://dx.doi.org/10.1038/s41467-019-11662-3

Ejemplares similares

WNT/β-catenin-suppressed FTO expression increases m(6)A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis
por: Yang, Xueying, et al.
Publicado: (2021)

TRIM36 inhibits tumorigenesis through the Wnt/β-catenin pathway and promotes caspase-dependent apoptosis in hepatocellular carcinoma
por: Tong, Qing, et al.
Publicado: (2022)

Myc is required for β-catenin-mediated mammary stem cell amplification and tumorigenesis
por: Moumen, Mejdi, et al.
Publicado: (2013)

Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression
por: Xu, Xinyuan, et al.
Publicado: (2015)

Oncogenic virus-induced aerobic glycolysis and tumorigenesis
por: Yu, Li, et al.
Publicado: (2018)

DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis
por: Zhang, Zhenxing, et al.
Publicado: (2021)

The c-Myc–LDHA axis positively regulates aerobic glycolysis and promotes tumor progression in pancreatic cancer
por: He, Tian-Lin, et al.
Publicado: (2015)

Cobalt Chloride Induced Apoptosis by Inhibiting GPC3 Expression via the HIF-1α/c-Myc Axis in HepG2 Cells
por: Tong, Yaoyao, et al.
Publicado: (2019)

The Molecular ‘Myc-anisms’ Behind Myc-Driven Tumorigenesis and the Relevant Myc-Directed Therapeutics
por: McAnulty, Jessica, et al.
Publicado: (2020)

Significance of Glypican-3 (GPC3) Expression in Hepatocellular Cancer Diagnosis
por: Sun, Bin, et al.
Publicado: (2017)

Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression
por: Li, Gong-Quan, et al.
Publicado: (2015)

Association of common variation in ADD3 and GPC1 with biliary atresia susceptibility
por: Bai, Mei-Rong, et al.
Publicado: (2020)

A Nucleolar Isoform of the Drosophila Ubiquitin Specific Protease dUSP36 Regulates MYC-Dependent Cell Growth
por: Thevenon, Dominique, et al.
Publicado: (2020)

IL‐36γ and IL‐36Ra Reciprocally Regulate Colon Inflammation and Tumorigenesis by Modulating the Cell–Matrix Adhesion Network and Wnt Signaling
por: Yang, Wei, et al.
Publicado: (2022)

Dioscin Inhibited Glycolysis and Induced Cell Apoptosis in Colorectal Cancer via Promoting c-myc Ubiquitination and Subsequent Hexokinase-2 Suppression
por: Wu, Zhenqian, et al.
Publicado: (2020)

WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 expression in an m(6)A-dependent manner
por: Chen, Shijie, et al.
Publicado: (2020)

C-MYC and BCL-2 mediate YAP-regulated tumorigenesis in OSCC
por: Chen, Xiyan, et al.
Publicado: (2017)

ENGINEERING T CELLS TARGETING GPC2 FOR TREATING NEUROBLASTOMA
por: Quan, Alex, et al.
Publicado: (2023)

Identification of GPC3 mutation and upregulation in a multidrug resistant osteosarcoma and its spheroids as therapeutic target
por: Nie, Jun-Hua, et al.
Publicado: (2021)

β-catenin in epithelial tumorigenesis
por: Lu, Tsai-Ling, et al.
Publicado: (2015)

YAP and β-catenin cooperate to drive H. pylori-induced gastric tumorigenesis
por: Li, Nianshuang, et al.
Publicado: (2023)

On the Role of Glycolysis in Early Tumorigenesis—Permissive and Executioner Effects
por: Marcucci, Fabrizio, et al.
Publicado: (2023)

Writing and erasing MYC ubiquitination and SUMOylation
por: Chen, Yingxiao, et al.
Publicado: (2019)

EI24 Suppresses Tumorigenesis in Pancreatic Cancer via Regulating c-Myc
por: Zang, Yi, et al.
Publicado: (2018)

Long non-coding RNA PVT1 interacts with MYC and its downstream molecules to synergistically promote tumorigenesis
por: Jin, Ke, et al.
Publicado: (2019)

Ubiquitin signaling in cell cycle control and tumorigenesis
por: Dang, Fabin, et al.
Publicado: (2020)

Pim1 promotes cell proliferation and regulates glycolysis via interaction with MYC in ovarian cancer
por: Wu, Yong, et al.
Publicado: (2018)

ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis
por: Liu, Xue-Song, et al.
Publicado: (2014)

Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer
por: Cargill, Kasey R., et al.
Publicado: (2021)

Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer
por: Zhang, Xiujuan, et al.
Publicado: (2022)

GPC-3 in hepatocellular carcinoma: current perspectives
por: Wu, Yongle, et al.
Publicado: (2016)

MiR-638 Repressed Vascular Smooth Muscle Cell Glycolysis by Targeting LDHA
por: Chen, Shiyuan, et al.
Publicado: (2019)

The roles of protein ubiquitination in tumorigenesis and targeted drug discovery in lung cancer
por: Ye, Zhen, et al.
Publicado: (2023)

A Hypoxia-Induced SCF(FBXL1) E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis
por: Zeng, Jun, et al.
Publicado: (2022)

EBV reactivation as a target of luteolin to repress NPC tumorigenesis
por: Wu, Chung-Chun, et al.
Publicado: (2016)

Ubiquitination by HUWE1 in tumorigenesis and beyond
por: Kao, Shih-Han, et al.
Publicado: (2018)

Structural basis of JAZ repression of MYC transcription factors in jasmonate signaling
por: Zhang, Feng, et al.
Publicado: (2015)

Low glucose metabolism in hepatocellular carcinoma with GPC3 expression
por: Li, You-Cai, et al.
Publicado: (2018)

The TRPM7 channel reprograms cellular glycolysis to drive tumorigenesis and angiogenesis
por: Wu, Wanzhou, et al.
Publicado: (2023)

SDHB Suppresses the Tumorigenesis and Development of ccRCC by Inhibiting Glycolysis
por: Fang, Zhiyu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_o231i3jkdnshl8qpt7dvqklm20