Interrogating Mutant Allele Expression via Customized Reference Genomes to Define Influential Cancer Mutations

Genetic alterations are essential for cancer initiation and progression. However, differentiating mutations that drive the tumor phenotype from mutations that do not affect tumor fitness remains a fundamental challenge in cancer biology. To better understand the impact of a given mutation within can...

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Detalles Bibliográficos
Autores principales: Grant, Adam D., Vail, Paris, Padi, Megha, Witkiewicz, Agnieszka K., Knudsen, Erik S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726654/
https://www.ncbi.nlm.nih.gov/pubmed/31484939
http://dx.doi.org/10.1038/s41598-019-48967-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726654/
https://www.ncbi.nlm.nih.gov/pubmed/31484939
http://dx.doi.org/10.1038/s41598-019-48967-8

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