Structural determinants of CO(2)-sensitivity in the β connexin family suggested by evolutionary analysis

A subclade of connexins comprising Cx26, Cx30, and Cx32 are directly sensitive to CO(2). CO(2) binds to a carbamylation motif present in these connexins and causes their hemichannels to open. Cx26 may contribute to CO(2)-dependent regulation of breathing in mammals. Here, we show that the carbamylat...

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Detalles Bibliográficos
Autores principales: Dospinescu, Valentin-Mihai, Nijjar, Sarbjit, Spanos, Fokion, Cook, Jonathan, de Wolf, Elizabeth, Biscotti, Maria Assunta, Gerdol, Marco, Dale, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726660/
https://www.ncbi.nlm.nih.gov/pubmed/31508505
http://dx.doi.org/10.1038/s42003-019-0576-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726660/
https://www.ncbi.nlm.nih.gov/pubmed/31508505
http://dx.doi.org/10.1038/s42003-019-0576-2

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