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Structural determinants of CO(2)-sensitivity in the β connexin family suggested by evolutionary analysis
A subclade of connexins comprising Cx26, Cx30, and Cx32 are directly sensitive to CO(2). CO(2) binds to a carbamylation motif present in these connexins and causes their hemichannels to open. Cx26 may contribute to CO(2)-dependent regulation of breathing in mammals. Here, we show that the carbamylat...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726660/ https://www.ncbi.nlm.nih.gov/pubmed/31508505 http://dx.doi.org/10.1038/s42003-019-0576-2 |