Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy

Constitutive expression of the chemokine Mcp1 in mouse cardiomyocytes creates a model of inflammatory cardiomyopathy, with death from heart failure at age 7–8 months. A critical pathogenic role has previously been proposed for induced oxidative stress, involving NADPH oxidase activation. To test thi...

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Detalles Bibliográficos
Autores principales: Dhandapani, Praveen K., Begines-Moreno, Isabel M., Brea-Calvo, Gloria, Gärtner, Ulrich, Graeber, Thomas G., Javier Sanchez, Gerardo, Morty, Rory E., Schönig, Kai, Hoeve, Johanna ten, Wietelmann, Astrid, Braun, Thomas, Jacobs, Howard T., Szibor, Marten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726756/
https://www.ncbi.nlm.nih.gov/pubmed/31484989
http://dx.doi.org/10.1038/s41598-019-49231-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726756/
https://www.ncbi.nlm.nih.gov/pubmed/31484989
http://dx.doi.org/10.1038/s41598-019-49231-9

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