Calcineurin regulates cyclin D1 stability through dephosphorylation at T286

The Calcineurin/NFAT (nuclear factor of activated T cells) pathway plays an essential role in the tumorigenic and metastatic properties in breast cancer. The molecular mechanism of the antiproliferative effect of calcineurin inhibition, however, is poorly understood. We found that calcineurin inhibi...

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Detalles Bibliográficos
Autores principales: Goshima, Takahiro, Habara, Makoto, Maeda, Keisuke, Hanaki, Shunsuke, Kato, Yoichi, Shimada, Midori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726757/
https://www.ncbi.nlm.nih.gov/pubmed/31484966
http://dx.doi.org/10.1038/s41598-019-48976-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726757/
https://www.ncbi.nlm.nih.gov/pubmed/31484966
http://dx.doi.org/10.1038/s41598-019-48976-7

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