Discovery and characterization of a small‐molecule enteropeptidase inhibitor, SCO‐792

Enteropeptidase, localized into the duodenum brush border, is a key enzyme catalyzing the conversion of pancreatic trypsinogen proenzyme to active trypsin, thereby regulating protein digestion and energy homeostasis. We report the discovery and pharmacological profiles of SCO‐792, a novel inhibitor...

Descripción completa

Detalles Bibliográficos
Autores principales: Sasaki, Masako, Miyahisa, Ikuo, Itono, Sachiko, Yashiro, Hiroaki, Hiyoshi, Hideyuki, Tsuchimori, Kazue, Hamagami, Ken‐ichi, Moritoh, Yusuke, Watanabe, Masanori, Tohyama, Kimio, Sasaki, Minoru, Sakamoto, Jun‐ichi, Kawamoto, Tomohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726858/
https://www.ncbi.nlm.nih.gov/pubmed/31508234
http://dx.doi.org/10.1002/prp2.517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726858/
https://www.ncbi.nlm.nih.gov/pubmed/31508234
http://dx.doi.org/10.1002/prp2.517

Ejemplares similares