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Prolines Affect the Nucleation Phase of Amyloid Fibrillation Reaction; Mutational Analysis of Human Stefin B
[Image: see text] Proline residues play a prominent role in protein folding and aggregation. We investigated the influence of single prolines and their combination on oligomerization and the amyloid fibrillation reaction of human stefin B (stB). The proline mutants influenced the distribution of oli...
Autores principales: | Hasanbašić, Samra, Taler-Verčič, Ajda, Puizdar, Vida, Stoka, Veronika, Tušek Žnidarič, Magda, Vilfan, Andrej, Berbić, Selma, Žerovnik, Eva |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2019
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727212/ https://www.ncbi.nlm.nih.gov/pubmed/30924329 http://dx.doi.org/10.1021/acschemneuro.8b00621 |
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