Inhibitory short peptides targeting EPS8/ABI1/SOS1 tri-complex suppress invasion and metastasis of ovarian cancer cells

BACKGROUND: We aimed to develop inhibitory short peptides that can prevent protein interactions of SOS1/EPS8/ABI1 tri-complex, a key component essential for ovarian cancer metastasis. METHODS: Plasmids containing various regions of HA-tagged ABI1 were co-transfected into ovarian cancer cells with Fl...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Xuechen, Liang, Chuan, Zhang, Yuanzhen, Zhang, Wei, Chen, Huijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727365/
https://www.ncbi.nlm.nih.gov/pubmed/31488087
http://dx.doi.org/10.1186/s12885-019-6087-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727365/
https://www.ncbi.nlm.nih.gov/pubmed/31488087
http://dx.doi.org/10.1186/s12885-019-6087-1

Ejemplares similares