N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells

BACKGROUND: KIT tyrosine kinase is expressed in mast cells, interstitial cells of Cajal, and hematopoietic cells. Permanently active KIT mutations lead these host cells to tumorigenesis, and to such diseases as mast cell leukemia (MCL), gastrointestinal stromal tumor (GIST), and acute myeloid leukem...

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Detalles Bibliográficos
Autores principales: Obata, Yuuki, Hara, Yasushi, Shiina, Isamu, Murata, Takatsugu, Tasaki, Yasutaka, Suzuki, Kyohei, Ito, Keiichi, Tsugawa, Shou, Yamawaki, Kouhei, Takahashi, Tsuyoshi, Okamoto, Koji, Nishida, Toshirou, Abe, Ryo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727407/
https://www.ncbi.nlm.nih.gov/pubmed/31484543
http://dx.doi.org/10.1186/s12964-019-0426-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727407/
https://www.ncbi.nlm.nih.gov/pubmed/31484543
http://dx.doi.org/10.1186/s12964-019-0426-3

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