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N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells
BACKGROUND: KIT tyrosine kinase is expressed in mast cells, interstitial cells of Cajal, and hematopoietic cells. Permanently active KIT mutations lead these host cells to tumorigenesis, and to such diseases as mast cell leukemia (MCL), gastrointestinal stromal tumor (GIST), and acute myeloid leukem...
Autores principales: | Obata, Yuuki, Hara, Yasushi, Shiina, Isamu, Murata, Takatsugu, Tasaki, Yasutaka, Suzuki, Kyohei, Ito, Keiichi, Tsugawa, Shou, Yamawaki, Kouhei, Takahashi, Tsuyoshi, Okamoto, Koji, Nishida, Toshirou, Abe, Ryo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727407/ https://www.ncbi.nlm.nih.gov/pubmed/31484543 http://dx.doi.org/10.1186/s12964-019-0426-3 |
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