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Human NK Cell Development: One Road or Many?

CD3(−)CD56(+) NK cells develop from CD34(+) hematopoietic progenitors (HPCs) in vivo, and this process can be recapitulated in vitro. The prevailing model is that human NK cell development occurs along a continuum whereby common lymphocyte progenitors (CLPs) gradually downregulate CD34 and upregulat...

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Detalles Bibliográficos
Autores principales: Cichocki, Frank, Grzywacz, Bartosz, Miller, Jeffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727427/
https://www.ncbi.nlm.nih.gov/pubmed/31555287
http://dx.doi.org/10.3389/fimmu.2019.02078