A predictive computational model reveals that GIV/girdin serves as a tunable valve for EGFR-stimulated cyclic AMP signals

Cellular levels of the versatile second messenger cyclic (c)AMP are regulated by the antagonistic actions of the canonical G protein → adenylyl cyclase pathway that is initiated by G-protein–coupled receptors (GPCRs) and attenuated by phosphodiesterases (PDEs). Dysregulated cAMP signaling drives man...

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Detalles Bibliográficos
Autores principales: Getz, Michael, Swanson, Lee, Sahoo, Debashish, Ghosh, Pradipta, Rangamani, Padmini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727633/
https://www.ncbi.nlm.nih.gov/pubmed/31017840
http://dx.doi.org/10.1091/mbc.E18-10-0630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727633/
https://www.ncbi.nlm.nih.gov/pubmed/31017840
http://dx.doi.org/10.1091/mbc.E18-10-0630

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