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Functional analysis and importance for host cell infection of the Ca(2+)-conducting subunits of the mitochondrial calcium uniporter of Trypanosoma cruzi

We report here that Trypanosoma cruzi, the etiologic agent of Chagas disease, possesses two unique paralogues of the mitochondrial calcium uniporter complex TcMCU subunit that we named TcMCUc and TcMCUd. The predicted structure of the proteins indicates that, as predicted for the TcMCU and TcMCUb pa...

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Detalles Bibliográficos
Autores principales: Chiurillo, Miguel A., Lander, Noelia, Bertolini, Mayara S., Vercesi, Anibal E., Docampo, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727756/
https://www.ncbi.nlm.nih.gov/pubmed/31091170
http://dx.doi.org/10.1091/mbc.E19-03-0152