Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces

Antibodies developed for research and clinical applications may exhibit suboptimal stability, expressibility, or affinity. Existing optimization strategies focus on surface mutations, whereas natural affinity maturation also introduces mutations in the antibody core, simultaneously improving stabili...

Descripción completa

Detalles Bibliográficos
Autores principales: Warszawski, Shira, Borenstein Katz, Aliza, Lipsh, Rosalie, Khmelnitsky, Lev, Ben Nissan, Gili, Javitt, Gabriel, Dym, Orly, Unger, Tamar, Knop, Orli, Albeck, Shira, Diskin, Ron, Fass, Deborah, Sharon, Michal, Fleishman, Sarel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728052/
https://www.ncbi.nlm.nih.gov/pubmed/31442220
http://dx.doi.org/10.1371/journal.pcbi.1007207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728052/
https://www.ncbi.nlm.nih.gov/pubmed/31442220
http://dx.doi.org/10.1371/journal.pcbi.1007207

Ejemplares similares