Production of metabolites of the anti-cancer drug noscapine using a P450(BM3) mutant library

Cytochrome P450 enzymes are a promising tool for the late-stage diversification of lead drug candidates and can provide an alternative route to structural modifications that are difficult to achieve with synthetic chemistry. In this study, a library of P450(BM3) mutants was produced using site-direc...

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Detalles Bibliográficos
Autores principales: Richards, Luke, Lutz, Adrian, Chalmers, David K., Jarrold, Ailsa, Bowser, Tim, Stevens, Geoffrey W., Gras, Sally L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728265/
https://www.ncbi.nlm.nih.gov/pubmed/31516852
http://dx.doi.org/10.1016/j.btre.2019.e00372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728265/
https://www.ncbi.nlm.nih.gov/pubmed/31516852
http://dx.doi.org/10.1016/j.btre.2019.e00372

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