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Production of metabolites of the anti-cancer drug noscapine using a P450(BM3) mutant library

Cytochrome P450 enzymes are a promising tool for the late-stage diversification of lead drug candidates and can provide an alternative route to structural modifications that are difficult to achieve with synthetic chemistry. In this study, a library of P450(BM3) mutants was produced using site-direc...

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Detalles Bibliográficos
Autores principales:	Richards, Luke, Lutz, Adrian, Chalmers, David K., Jarrold, Ailsa, Bowser, Tim, Stevens, Geoffrey W., Gras, Sally L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728265/ https://www.ncbi.nlm.nih.gov/pubmed/31516852 http://dx.doi.org/10.1016/j.btre.2019.e00372

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