LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer’s Disease

The low-density lipoprotein receptor-related protein-1 (LRP1) has a dual role in the metabolism of the amyloid precursor protein (APP). In cellular models, LRP1 enhances amyloid-β (Aβ) generation via APP internalization and thus its amyloidogenic processing. However, conditional knock-out studies in...

Descripción completa

Detalles Bibliográficos
Autores principales: Van Gool, Bart, Storck, Steffen E., Reekmans, Sara M., Lechat, Benoit, Gordts, Philip L. S. M., Pradier, Laurent, Pietrzik, Claus U., Roebroek, Anton J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728278/
https://www.ncbi.nlm.nih.gov/pubmed/31004319
http://dx.doi.org/10.1007/s12035-019-1594-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728278/
https://www.ncbi.nlm.nih.gov/pubmed/31004319
http://dx.doi.org/10.1007/s12035-019-1594-2

Ejemplares similares