Crystal structure and chemical inhibition of essential schistosome host-interactive virulence factor carbonic anhydrase SmCA

The intravascular parasitic worm Schistosoma mansoni is a causative agent of schistosomiasis, a disease of great global public health significance. Here we identify an α-carbonic anhydrase (SmCA) that is expressed at the schistosome surface as determined by activity assays and immunofluorescence/imm...

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Detalles Bibliográficos
Autores principales: Da’dara, Akram A., Angeli, Andrea, Ferraroni, Marta, Supuran, Claudiu T., Skelly, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728359/
https://www.ncbi.nlm.nih.gov/pubmed/31508507
http://dx.doi.org/10.1038/s42003-019-0578-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728359/
https://www.ncbi.nlm.nih.gov/pubmed/31508507
http://dx.doi.org/10.1038/s42003-019-0578-0

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