Cargando…
Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank
Insulin drives growth and reproduction which trade-off against longevity. Genetically predicted insulin, i.e., insulin proxied by genetic variants, is positively associated with ischemic heart disease, but sex differences are unclear, despite different disease rates and reproductive strategies by se...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728387/ https://www.ncbi.nlm.nih.gov/pubmed/31508506 http://dx.doi.org/10.1038/s42003-019-0579-z |
_version_ | 1783449428630175744 |
---|---|
author | Zhao, Jie V. Luo, Shan Schooling, C. Mary |
author_facet | Zhao, Jie V. Luo, Shan Schooling, C. Mary |
author_sort | Zhao, Jie V. |
collection | PubMed |
description | Insulin drives growth and reproduction which trade-off against longevity. Genetically predicted insulin, i.e., insulin proxied by genetic variants, is positively associated with ischemic heart disease, but sex differences are unclear, despite different disease rates and reproductive strategies by sex. We used Mendelian randomization in 392,010 white British from the UK Biobank to assess the sex-specific role of genetically predicted insulin in myocardial infarction (MI) (14,442 cases, 77% men), angina (21,939 cases, 65% men) and heart failure (5537 cases, 71% men). Genetically predicted insulin was associated with MI (odds ratio (OR) 4.27 per pmol/L higher insulin, 95% confidence interval (CI) 1.60 to 11.3) and angina (OR 2.93, 1.27 to 6.73) in men, but not women (MI OR 0.80, 95% CI 0.23 to 2.84, angina OR 1.10, 95% CI 0.38 to 3.18). Patterns were similar for insulin resistance and heart failure. Mitigating the effects of insulin might address sexual disparities in health. |
format | Online Article Text |
id | pubmed-6728387 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-67283872019-09-10 Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank Zhao, Jie V. Luo, Shan Schooling, C. Mary Commun Biol Article Insulin drives growth and reproduction which trade-off against longevity. Genetically predicted insulin, i.e., insulin proxied by genetic variants, is positively associated with ischemic heart disease, but sex differences are unclear, despite different disease rates and reproductive strategies by sex. We used Mendelian randomization in 392,010 white British from the UK Biobank to assess the sex-specific role of genetically predicted insulin in myocardial infarction (MI) (14,442 cases, 77% men), angina (21,939 cases, 65% men) and heart failure (5537 cases, 71% men). Genetically predicted insulin was associated with MI (odds ratio (OR) 4.27 per pmol/L higher insulin, 95% confidence interval (CI) 1.60 to 11.3) and angina (OR 2.93, 1.27 to 6.73) in men, but not women (MI OR 0.80, 95% CI 0.23 to 2.84, angina OR 1.10, 95% CI 0.38 to 3.18). Patterns were similar for insulin resistance and heart failure. Mitigating the effects of insulin might address sexual disparities in health. Nature Publishing Group UK 2019-09-05 /pmc/articles/PMC6728387/ /pubmed/31508506 http://dx.doi.org/10.1038/s42003-019-0579-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zhao, Jie V. Luo, Shan Schooling, C. Mary Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank |
title | Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank |
title_full | Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank |
title_fullStr | Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank |
title_full_unstemmed | Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank |
title_short | Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank |
title_sort | sex-specific mendelian randomization study of genetically predicted insulin and cardiovascular events in the uk biobank |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728387/ https://www.ncbi.nlm.nih.gov/pubmed/31508506 http://dx.doi.org/10.1038/s42003-019-0579-z |
work_keys_str_mv | AT zhaojiev sexspecificmendelianrandomizationstudyofgeneticallypredictedinsulinandcardiovasculareventsintheukbiobank AT luoshan sexspecificmendelianrandomizationstudyofgeneticallypredictedinsulinandcardiovasculareventsintheukbiobank AT schoolingcmary sexspecificmendelianrandomizationstudyofgeneticallypredictedinsulinandcardiovasculareventsintheukbiobank |