Cargando…

Inhibition of phosphatidylinositol 3‐kinase α (PI3Kα) prevents heterotopic ossification

Heterotopic ossification (HO) is the pathological formation of ectopic endochondral bone within soft tissues. HO occurs following mechanical trauma, burns, or congenitally in patients suffering from fibrodysplasia ossificans progressiva (FOP). FOP patients carry a conserved mutation in ACVR1 that be...

Descripción completa

Detalles Bibliográficos
Autores principales:	Valer, José Antonio, Sánchez‐de‐Diego, Cristina, Gámez, Beatriz, Mishina, Yuji, Rosa, José Luis, Ventura, Francesc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728602/ https://www.ncbi.nlm.nih.gov/pubmed/31373426 http://dx.doi.org/10.15252/emmm.201910567

Ejemplares similares

PI3K (Phosphatidylinositol 3-Kinase) Activation and Endothelial Cell Proliferation in Patients with Hemorrhagic Hereditary Telangiectasia Type 1
por: Iriarte, Adriana, et al.
Publicado: (2019)

Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics
por: Akinleye, Akintunde, et al.
Publicado: (2013)

Methods for the reliable induction of heterotopic ossification in the conditional Alk2(Q207D) mouse
por: Pan, Haichun, et al.
Publicado: (2020)

Characterization of Cells Isolated from Genetic and Trauma-Induced Heterotopic Ossification
por: Agarwal, Shailesh, et al.
Publicado: (2016)

Heterotopic Ossification in the Gallbladder
por: Ahn, Jihyun, et al.
Publicado: (2017)

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α
por: Lo, Wen-Ting, et al.
Publicado: (2022)

Structural basis of phosphatidylinositol 3-kinase C2α function
por: Lo, Wen-Ting, et al.
Publicado: (2022)

Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification
por: Hwang, Charles, et al.
Publicado: (2019)

Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer
por: Knowles, Margaret A., et al.
Publicado: (2009)

Critical implication of the PTEN/PI3K/AKT pathway during BMP2-induced heterotopic ossification
por: Dong, Jun, et al.
Publicado: (2021)

Characterization of Heterotopic Ossification Using Radiographic Imaging: Evidence for a Paradigm Shift
por: Brownley, R. Cameron, et al.
Publicado: (2015)

Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice
por: Wang, Xiao, et al.
Publicado: (2018)

Potent Inhibition of Heterotopic Ossification by Nuclear Retinoic Acid Receptor γ Agonists
por: Shimono, Kengo, et al.
Publicado: (2011)

Pulmonary Adenocarcinoma with Heterotopic Ossification
por: Kim, Gou Young, et al.
Publicado: (2009)

Blast injuries and heterotopic ossification
por: Alfieri, K. A., et al.
Publicado: (2012)

Heterotopic Ossification: An Unusual Presentation
por: Patil, Satish G., et al.
Publicado: (2012)

Heterotopic Ossification in Breast Prosthesis
por: Fradinho, Nuno, et al.
Publicado: (2015)

Heterotopic Ossification of Brachialis Muscle
por: George, Jacob
Publicado: (2005)

Heterotopic ossification of tendon and ligament
por: Zhang, Qiang, et al.
Publicado: (2020)

Contemporary perspectives on heterotopic ossification
por: Hwang, Charles D., et al.
Publicado: (2022)

Heterotopic Ossification in Hip Arthroscopy
por: Seijas, Roberto, et al.
Publicado: (2023)

Association of α(2)-HS Glycoprotein with Neurogenic Heterotopic Ossification in Patients with Spinal Cord Injury
por: Dong, Liwei, et al.
Publicado: (2017)

Abstract 86: Systemic Inhibition of Tgfβ Signaling Attenuates Trauma-induced Heterotopic Ossification
por: Patel, Nicole, et al.
Publicado: (2018)

Differential Effects of Phosphatidylinositol 4-Kinase (PI4K) and 3-Kinase (PI3K) Inhibitors on Stomatal Responses to Environmental Signals
por: Takahashi, Sho, et al.
Publicado: (2017)

Class IA Phosphatidylinositol 3-Kinase p110α Regulates Phagosome Maturation
por: Thi, Emily P., et al.
Publicado: (2012)

Role of Phosphatidylinositol 3-Kinase (PI3K), Mitogen-Activated Protein Kinase (MAPK), and Protein Kinase C (PKC) in Calcium Signaling Pathways Linked to the α(1)-Adrenoceptor in Resistance Arteries
por: Gutiérrez, Alejandro, et al.
Publicado: (2019)

Phosphatidylinositol 3-kinase (PI3Kα)/AKT axis blockade with taselisib or ipatasertib enhances the efficacy of anti-microtubule drugs in human breast cancer cells
por: Morgillo, Floriana, et al.
Publicado: (2017)

Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β
por: Ito, Yoshihiro, et al.
Publicado: (2017)

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P(3)) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin α(IIb)β(3) Outside-in Signaling
por: Battram, Anthony M., et al.
Publicado: (2017)

Prophylaxis of heterotopic ossification – an updated review
por: Baird, Evan O, et al.
Publicado: (2009)

Animal Models of Typical Heterotopic Ossification
por: Kan, Lixin, et al.
Publicado: (2011)

Heterotopic ossification after hip arthroscopy
por: Amar, Eyal, et al.
Publicado: (2015)

Heterotopic Ossification: A Comprehensive Review
por: Meyers, Carolyn, et al.
Publicado: (2019)

Heterotopic Ossification: Radiological and Pathological Review
por: Mujtaba, Bilal, et al.
Publicado: (2019)

Surgical Management of Shoulder Heterotopic Ossification
por: Hallock, Justin, et al.
Publicado: (2019)

Retinoid Agonists in the Targeting of Heterotopic Ossification
por: Pignolo, Robert J., et al.
Publicado: (2021)

New Strategies in Neurogenic Heterotopic Ossification
por: Ampadiotaki, Margarita-Michaela, et al.
Publicado: (2021)

Heterotopic Mesenteric Ossification With Trilineage Hematopoiesis
por: Martinbianco, Emily M, et al.
Publicado: (2022)

Neurotrophin‐3 acts on the endothelial‐mesenchymal transition of heterotopic ossification in rats
por: Zhang, Jie, et al.
Publicado: (2019)

Phosphatidylinositol 3-Kinase (PI3K) δ blockade increases genomic instability in B cells
por: Compagno, Mara, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_sppolpj9rthlolr96ngfaeguvh