Iron Dyshomeostasis Induces Binding of APP to BACE1 for Amyloid Pathology, and Impairs APP/Fpn1 Complex in Microglia: Implication in Pathogenesis of Cerebral Microbleeds

As a putative marker of cerebral small vessel disease, cerebral microbleeds (CMBs) have been associated with vascular cognitive impairment. Both iron accumulation and amyloid protein precursor (APP) dysregulation are recognized as pathological hallmarks underlying the progression of CMBs, but their...

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Detalles Bibliográficos
Autores principales: Gong, Li, Tian, Xiangzhu, Zhou, Jing, Dong, Qiong, Tan, Yan, Lu, You, Wu, Jiayan, Zhao, Yanxin, Liu, Xueyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728710/
https://www.ncbi.nlm.nih.gov/pubmed/30776900
http://dx.doi.org/10.1177/0963689719831707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728710/
https://www.ncbi.nlm.nih.gov/pubmed/30776900
http://dx.doi.org/10.1177/0963689719831707

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