Crystal structure of 6aJL2-R24G light chain variable domain: Does crystal packing explain amyloid fibril formation?

Light chain amyloidosis is one of the most common systemic amyloidosis, characterized by the deposition of immunoglobulin light variable domain as insoluble amyloid fibrils in vital organs, leading to the death of patients. Germline λ6a is closely related with this disease and has been reported that...

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Detalles Bibliográficos
Autores principales: Rudiño-Piñera, Enrique, Peláez-Aguilar, Ángel E., Amero, Carlos, Díaz-Vilchis, Adelaida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728755/
https://www.ncbi.nlm.nih.gov/pubmed/31517067
http://dx.doi.org/10.1016/j.bbrep.2019.100682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728755/
https://www.ncbi.nlm.nih.gov/pubmed/31517067
http://dx.doi.org/10.1016/j.bbrep.2019.100682

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