Dynamic profiles, biodistribution and integration evaluation after intramuscular/intravenous delivery of a novel therapeutic DNA vaccine encoding chicken type II collagen for rheumatoid arthritis in vaccinated normal rodent

BACKGROUND: The persistence, biodistribution, and risk of integration into the host genome of any new therapeutic DNA vaccine must be established in preclinical studies. We previously developed the DNA vaccine pcDNA-CCOL2A1 encoding chicken type II collagen (CCII) for the treatment of rheumatoid art...

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Detalles Bibliográficos
Autores principales: Zhao, Xiao, Long, Juan, Liang, Fei, Liu, Nan, Sun, Yuying, Xi, Yongzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729025/
https://www.ncbi.nlm.nih.gov/pubmed/31492169
http://dx.doi.org/10.1186/s12951-019-0528-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729025/
https://www.ncbi.nlm.nih.gov/pubmed/31492169
http://dx.doi.org/10.1186/s12951-019-0528-5

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