Toxoplasma gondii activates a Syk-CARD9-NF-κB signaling axis and gasdermin D-independent release of IL-1β during infection of primary human monocytes

IL-1β is a potent pro-inflammatory cytokine that promotes immunity and host defense, and its dysregulation is associated with immune pathology. Toxoplasma gondii infection of myeloid cells triggers the production and release of IL-1β; however, the mechanisms regulating this pathway, particularly in...

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Detalles Bibliográficos
Autores principales: Pandori, William J., Lima, Tatiane S., Mallya, Sharmila, Kao, Tiffany H., Gov, Lanny, Lodoen, Melissa B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730955/
https://www.ncbi.nlm.nih.gov/pubmed/31449558
http://dx.doi.org/10.1371/journal.ppat.1007923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730955/
https://www.ncbi.nlm.nih.gov/pubmed/31449558
http://dx.doi.org/10.1371/journal.ppat.1007923

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