Cargando…
Regulation of Eag1 gating by its intracellular domains
Voltage-gated potassium channels (K(v)s) are gated by transmembrane voltage sensors (VS) that move in response to changes in membrane voltage. K(v)10.1 or Eag1 also has three intracellular domains: PAS, C-linker, and CNBHD. We demonstrate that the Eag1 intracellular domains are not required for volt...
Autores principales: | Whicher, Jonathan R, MacKinnon, Roderick |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731095/ https://www.ncbi.nlm.nih.gov/pubmed/31490124 http://dx.doi.org/10.7554/eLife.49188 |
Ejemplares similares
-
Voltage-sensor movements in the Eag Kv channel under an applied electric field
por: Mandala, Venkata Shiva, et al.
Publicado: (2022) -
Gating and regulation of KCNH (ERG, EAG, and ELK) channels by intracellular domains
por: Codding, Sara J., et al.
Publicado: (2020) -
Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP(2) and Na(+) in a reconstituted system
por: Wang, Weiwei, et al.
Publicado: (2014) -
The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers
por: Touhara, Kouki K, et al.
Publicado: (2016) -
The membrane electric field regulates the PIP(2)-binding site to gate the KCNQ1 channel
por: Mandala, Venkata Shiva, et al.
Publicado: (2023)