Cargando…

Drug repurposing for Alzheimer’s disease based on transcriptional profiling of human iPSC-derived cortical neurons

Alzheimer’s disease is a complex disorder encompassing multiple pathological features with associated genetic and molecular culprits. However, target-based therapeutic strategies have so far proved ineffective. The aim of this study is to develop a methodology harnessing the transcriptional changes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Williams, Gareth, Gatt, Ariana, Clarke, Earl, Corcoran, Jonathan, Doherty, Patrick, Chambers, David, Ballard, Clive
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731247/ https://www.ncbi.nlm.nih.gov/pubmed/31492831 http://dx.doi.org/10.1038/s41398-019-0555-x

Ejemplares similares

Transcription-based drug repurposing for COVID-19
por: Killick, Richard, et al.
Publicado: (2020)

Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical Neurons
por: Hedegaard, Anne, et al.
Publicado: (2020)

Human iPSC-Derived Cortical Neurons Display Homeostatic Plasticity
por: Cordella, Federica, et al.
Publicado: (2022)

Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons
por: Pozner, Tatyana, et al.
Publicado: (2018)

Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids
por: Osete, Jordi Requena, et al.
Publicado: (2023)

Limitations of the human iPSC-derived neuron model for early-onset Alzheimer’s disease
por: Valdes, Phoebe, et al.
Publicado: (2023)

Organ-Chips Enhance the Maturation of Human iPSC-Derived Dopamine Neurons
por: Otero, Maria G., et al.
Publicado: (2023)

Modeling anorexia nervosa: transcriptional insights from human iPSC-derived neurons
por: Negraes, P D, et al.
Publicado: (2017)

Faithful SGCE imprinting in iPSC-derived cortical neurons: an endogenous cellular model of myoclonus-dystonia
por: Grütz, Karen, et al.
Publicado: (2017)

Generation of a CHIP isogenic human iPSC-derived cortical neuron model for functional proteomics
por: Dias, Catarina, et al.
Publicado: (2022)

DNA Methyltransferase 1 (DNMT1) Shapes Neuronal Activity of Human iPSC-Derived Glutamatergic Cortical Neurons
por: Bachmann, Sarah, et al.
Publicado: (2021)

Identifying the dynamics of actin and tubulin polymerization in iPSCs and in iPSC-derived neurons
por: Magliocca, Valentina, et al.
Publicado: (2017)

Aberrant iPSC-derived human astrocytes in Alzheimer's disease
por: Jones, V C, et al.
Publicado: (2017)

Modeling Alzheimer’s disease with iPSC-derived brain cells
por: Penney, Jay, et al.
Publicado: (2019)

DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients
por: Corti, Alessandro, et al.
Publicado: (2019)

Molecular and functional variation in iPSC-derived sensory neurons
por: Schwartzentruber, Jeremy, et al.
Publicado: (2017)

Transcriptome Dynamics of Human Neuronal Differentiation From iPSC
por: Kuruş, Meltem, et al.
Publicado: (2021)

The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons
por: Ovchinnikov, Dmitry A., et al.
Publicado: (2018)

Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer’s Disease-Associated Presenilin 1 Mutation
por: Martín-Maestro, Patricia, et al.
Publicado: (2017)

Assessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer’s disease using patient iPSC-derived neurons
por: Wu, Pei-Chun, et al.
Publicado: (2019)

High-content analysis of neuronal morphology in human iPSC-derived neurons
por: Lickfett, Selene, et al.
Publicado: (2022)

Correction: Aberrant iPSC-derived human astrocytes in Alzheimer’s disease
por: Jones, V. C., et al.
Publicado: (2019)

APP-BACE1 Interaction and Intracellular Localization Regulate Aβ Production in iPSC-Derived Cortical Neurons
por: Roselli, Sandra, et al.
Publicado: (2023)

Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome
por: Tian, Yuan, et al.
Publicado: (2014)

Dendritic spine formation and synapse maturation in transcription factor-induced human iPSC-derived neurons
por: Lin, Waka, et al.
Publicado: (2023)

Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development
por: Sances, Samuel, et al.
Publicado: (2018)

Using Human iPSC-Derived Neurons to Model TAU Aggregation
por: Verheyen, An, et al.
Publicado: (2015)

Quantitative proteomic analysis of Rett iPSC-derived neuronal progenitors
por: Varderidou-Minasian, Suzy, et al.
Publicado: (2020)

Preparation and Co‐Culture of iPSC‐Derived Dopaminergic Neurons and Astrocytes
por: de Rus Jacquet, Aurelie
Publicado: (2019)

Automated high-content imaging in iPSC-derived neuronal progenitors
por: Papandreou, Apostolos, et al.
Publicado: (2023)

iPSC screening for drug repurposing identifies anti‐RNA virus agents modulating host cell susceptibility
por: Imamura, Keiko, et al.
Publicado: (2021)

Identification of potential transcription factors that enhance human iPSC generation
por: Swaidan, Nuha T., et al.
Publicado: (2020)

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons
por: van der Kant, Rik, et al.
Publicado: (2019)

Recent advances in human iPSC-derived models of the blood–brain barrier
por: Workman, Michael J., et al.
Publicado: (2020)

iPSC Modeling of Presenilin1 Mutation in Alzheimer's Disease with Cerebellar Ataxia
por: Li, Ling, et al.
Publicado: (2018)

REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease
por: Meyer, Katharina, et al.
Publicado: (2019)

Altered spinogenesis in iPSC-derived cortical neurons from patients with autism carrying de novo SHANK3 mutations
por: Gouder, Laura, et al.
Publicado: (2019)

Transcriptional signatures in iPSC-derived neurons are reproducible across labs when differentiation protocols are closely matched
por: Reed, Xylena, et al.
Publicado: (2021)

Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects
por: Workman, Michael J., et al.
Publicado: (2023)

Banking on iPSC- Is it Doable and is it Worthwhile
por: Solomon, Susan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_h5i2au74n1j1v5mn1t4dk1itti