Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection

Salmonella Typhi activates the host DNA damage response through the typhoid toxin, facilitating typhoid symptoms and chronic infections. Here we reveal a non-canonical DNA damage response, which we call RING (response induced by a genotoxin), characterized by accumulation of phosphorylated histone H...

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Detalles Bibliográficos
Autores principales: Ibler, Angela E. M., ElGhazaly, Mohamed, Naylor, Kathryn L., Bulgakova, Natalia A., F. El-Khamisy, Sherif, Humphreys, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731267/
https://www.ncbi.nlm.nih.gov/pubmed/31492859
http://dx.doi.org/10.1038/s41467-019-12064-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731267/
https://www.ncbi.nlm.nih.gov/pubmed/31492859
http://dx.doi.org/10.1038/s41467-019-12064-1

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