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Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection
Salmonella Typhi activates the host DNA damage response through the typhoid toxin, facilitating typhoid symptoms and chronic infections. Here we reveal a non-canonical DNA damage response, which we call RING (response induced by a genotoxin), characterized by accumulation of phosphorylated histone H...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731267/ https://www.ncbi.nlm.nih.gov/pubmed/31492859 http://dx.doi.org/10.1038/s41467-019-12064-1 |