ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis

The aldehyde dehydrogenase (ALDH) family of metabolic enzymes converts aldehydes to carboxylates. Here, we find that the reductive consequence of ALDH7A1 activity, which generates NADH (nicotinamide adenine dinucleotide, reduced form) from NAD, underlies how ALDH7A1 coordinates a broad inhibition of...

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Detalles Bibliográficos
Autores principales: Yang, Jia-Shu, Hsu, Jia-Wei, Park, Seung-Yeol, Lee, Stella Y., Li, Jian, Bai, Ming, Alves, Claudia, Tseng, William, Michelet, Xavier, Ho, I-Cheng, Hsu, Victor W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731274/
https://www.ncbi.nlm.nih.gov/pubmed/31492851
http://dx.doi.org/10.1038/s41467-019-11932-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731274/
https://www.ncbi.nlm.nih.gov/pubmed/31492851
http://dx.doi.org/10.1038/s41467-019-11932-0

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