Pharmacological mTOR targeting enhances the antineoplastic effects of selective PI3Kα inhibition in medulloblastoma

Despite recent advances in the treatment of medulloblastoma, patients in high-risk categories still face very poor outcomes. Evidence indicates that a subpopulation of cancer stem cells contributes to therapy resistance and tumour relapse in these patients. To prevent resistance and relapse, the dev...

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Detalles Bibliográficos
Autores principales: Eckerdt, Frank, Clymer, Jessica, Bell, Jonathan B., Beauchamp, Elspeth M., Blyth, Gavin T., Goldman, Stewart, Platanias, Leonidas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731286/
https://www.ncbi.nlm.nih.gov/pubmed/31492956
http://dx.doi.org/10.1038/s41598-019-49299-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731286/
https://www.ncbi.nlm.nih.gov/pubmed/31492956
http://dx.doi.org/10.1038/s41598-019-49299-3

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