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Etoposide-induced DNA damage in a chromosomal breakpoint of RUNX1 gene is independent of RUNX1 expression

In this work, we analyzed the association between RUNX1 gene expression and the accessibility of BCR3, one of RUNX1 gene breakpoint regions involved in the chromosomal translocation (8;21), a frequent translocation in treatment-related acute myeloid leukemia patients. To this end, we evaluate DNA da...

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Detalles Bibliográficos
Autores principales: Schnake, Nicolás, Gutiérrez, Soraya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731348/
https://www.ncbi.nlm.nih.gov/pubmed/31516823
http://dx.doi.org/10.1016/j.lrr.2019.100182