Deletion of a Single LeishIF4E-3 Allele by the CRISPR-Cas9 System Alters Cell Morphology and Infectivity of Leishmania

The genomes of Leishmania and trypanosomes encode six paralogs of the eIF4E cap-binding protein, known in other eukaryotes to anchor the translation initiation complex. In line with the heteroxenous nature of these parasites, the different LeishIF4E paralogs vary in their biophysical features and th...

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Detalles Bibliográficos
Autores principales: Shrivastava, Rohit, Tupperwar, Nitin, Drory-Retwitzer, Matan, Shapira, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731530/
https://www.ncbi.nlm.nih.gov/pubmed/31484740
http://dx.doi.org/10.1128/mSphere.00450-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731530/
https://www.ncbi.nlm.nih.gov/pubmed/31484740
http://dx.doi.org/10.1128/mSphere.00450-19

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