Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity

Human NAD(P)H quinone oxidoreductase (DT-diaphorase, NQO1) exhibits negative cooperativity towards its potent inhibitor, dicoumarol. Here, we addressed the hypothesis that the effects of the two cancer-associated polymorphisms (p.R139W and p.P187S) may be partly mediated by their effects on inhibito...

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Detalles Bibliográficos
Autores principales: Megarity, Clare F., Timson, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732362/
https://www.ncbi.nlm.nih.gov/pubmed/31431515
http://dx.doi.org/10.1042/BSR20191874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732362/
https://www.ncbi.nlm.nih.gov/pubmed/31431515
http://dx.doi.org/10.1042/BSR20191874

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